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Clinical studies in breastcancer have shown that a polymorphism in the MDM2 promoter, known as SNP309,affects the signi?cance of p53 mutation. Such needs include hungerand thirst, cleanliness and hygiene, and the appropriatetreatment of pain. However,there are some cases for which accurate differentiationbetween T1 and T2 is necessary. Interestingly, the number of gene therapy trials for monogenic diseases, themajority of rare diseases, has been increasing over the last decade to 8.7 % of allgene therapy trials in 2012. Kerati-nocytes are the most numerous ofthese cells; they are generated in the stratum basale and move toward the surface
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